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Differential diagnosis of thyroid nodules with US elastography using carotid artery pulsation

Manjiri Dighe1, Unmin Bae, Michael L Richardson

  • 1Department of Radiology, University of Washington Medical Center, Seattle, WA 98195, USA. dighe@u.washington.edu

Radiology
|June 10, 2008
PubMed

Insights

Ultrasonographic elastography using carotid artery pulsation can differentiate papillary carcinomas from other thyroid nodules. This method calculates a thyroid stiffness index, proving effective in diagnosis.

Area of Science:

  • Radiology
  • Medical Imaging
  • Oncology

Background:

  • Thyroid nodules require accurate diagnostic methods.
  • Ultrasonographic elastography offers a non-invasive approach to assess tissue stiffness.

Purpose of the Study:

  • To evaluate ultrasonographic (US) elastography using carotid arterial pulsation for differentiating thyroid nodules.
  • To determine the sensitivity and specificity of this novel elastography technique.

Main Methods:

  • Fifty-eight patients underwent US elastography with carotid artery pulsation before fine-needle aspiration.
  • Elastographic maps and thyroid stiffness index were calculated from downloaded US data.
  • Statistical analysis used the Kruskal-Wallis test in the R environment.

Main Results:

  • Papillary carcinomas (n=10) exhibited significantly greater stiffness than other thyroid lesions (n=43) (P < .0039).
  • The thyroid stiffness index effectively distinguished between papillary carcinomas and other nodule types.

Conclusions:

  • Ultrasonographic elastography with carotid arterial pulsation is a viable method for distinguishing papillary thyroid carcinomas.
  • The calculated thyroid stiffness index aids in the differential diagnosis of thyroid nodules.
Abstract

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