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Updated: Jul 4, 2026

Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
Mechanobiology of tooth movement
S Henneman1, J W Von den Hoff, J C Maltha
1Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, Postbus, Nijmegen, The Netherlands.
Abstract:
This review describes the mechanical and biological signalling pathways during orthodontic tooth movement and provides an update of the current literature. A theoretical model is introduced to elucidate the complex cascade of events after the application of an orthodontic force to a tooth. In this model, the events are divided into four stages: matrix strain and fluid flow, cell strain, cell activation and differentiation, and remodelling. Each stage is explained in detail and discussed using recent literature.
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