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Type C virus expression in lymphoma-paralysis-prone wild mice
Journal of the National Cancer Institute
|September 1, 1976
Summary
Infectious type C virus is common in wild Lake Casitas mice, causing disease. Host factors influence whether mice develop lymphoma or paralysis from this virus.
Area of Science:
- Virology
- Immunology
- Ecology
Background:
- Wild mice near Lake Casitas (LC) exhibit high prevalence of infectious type C virus.
- Infection is widespread by young adulthood, affecting various organs including genital tissues.
Purpose of the Study:
- To investigate the prevalence and impact of type C virus in LC wild mice.
- To understand the factors influencing disease development (lymphoma, paralysis) in infected mice.
Main Methods:
- Prevalence assessment of type C virus in wild-caught mice.
- Correlation of early-life serum gs antigen levels with disease outcomes.
- Observation of disease development (lymphoma, paralysis) under natural and experimental conditions.
Main Results:
- High prevalence of type C virus in young LC mice (liver, spleen, thymus).
- Approximately 80% of adult LC mice are infected, with virus present in genital tissues.
- Virus isolates cause lymphoma and paralysis; early serum gs antigen levels predict paralysis.
- Individual variation in virus expression suggests host defense mechanisms influence disease.
Conclusions:
- Type C virus infection is endemic in the LC wild mouse population.
- Host immune status and viral variations are critical determinants of disease susceptibility or resistance.
- Serum gs antigen may serve as an early indicator for paralysis development.