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Duration of renal failure as risk factor for conjunctival squamous metaplasia
Necati Demir1, Mustafa Altay, Elif Ozer
1Department of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkey.
Objective:
To assess ocular surface changes in patients with chronic renal failure (CRF), to compare the results with the duration of illness.
Study Design:
Impression cytology from 48 patients with CRF on regular hemodialysis and 16 age- and sex-matched control subjects were studied. Specimens were taken from the temporal bulbar conjunctiva using cellulose acetate filter paper.
Results:
Among the patients with CRF who were ill for 0-10 years, 25 patients (78.1%) disclosed grade 0-1, and 7 patients (21.9%) disclosed grade 2-3 cytologic changes, whereas in those with the duration of CRF > 10 years, 9 patients (56.2%) had grade 0-1 and 7 patients (43.8%) had grade 2-3 changes. Specimens from the control group revealed 93.8% grade 0-1 and 6.2% grade 2-3 changes (p < 0.05).
Conclusion:
The ocular surfaces of patients with CRF differ significantly from those of normal individuals, and the severity of conjunctival changes is related to the duration of CRF.
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