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Updated: Jul 4, 2026
08:51
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
[Classification of MS and treatment strategy]
1Department of Neurology, Kanazawa Medical University.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 11, 2008
Summary
Japanese patients with relapsing-remitting multiple sclerosis (RRMS) present in two forms: opticospinal (OSMS) and conventional (CMS). OSMS patients experience more frequent relapses and severe deficits, necessitating careful monitoring and treatment strategies.
Area of Science:
- Neurology
- Immunology
- Clinical Medicine
Context:
- Japanese patients with relapsing-remitting multiple sclerosis (RRMS) exhibit distinct clinical phenotypes.
- Two primary forms identified: opticospinal MS (OSMS) and conventional MS (CMS).
- OSMS is characterized by optic neuritis and myelitis, while CMS shares features with Western MS.
Purpose:
- To differentiate between OSMS and CMS in Japanese RRMS patients.
- To compare relapse frequency and neurological deficit severity between OSMS and CMS.
- To inform treatment strategies for different RRMS phenotypes in Japan.
Summary:
- OSMS patients experience more frequent relapses and greater neurological deficits compared to CMS patients.
- Acute exacerbations are treated with high-dose intravenous methylprednisolone; plasmapheresis is an option for non-responders.
- Interferon-beta is used for relapse prevention, but caution is advised for patients with extensive spinal cord lesions (over three vertebral segments) due to potential treatment failure.
Impact:
- Highlights the importance of recognizing distinct MS subtypes in Japanese populations.
- Informs clinical management by identifying risk factors for treatment failure.
- Contributes to a better understanding of MS heterogeneity and its impact on patient outcomes.
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