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Related Experiment Video

Updated: Jul 4, 2026

An Ex vivo Model to Study Hormone Action in the Human Breast

An Ex vivo Model to Study Hormone Action in the Human Breast

Published on: January 8, 2015

Progesterone receptor isoforms in normal and malignant breast.

P A Mote¹, J D Graham, C L Clarke

¹Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Darcy Rd, 2145 Westmead, Australia.

Ernst Schering Foundation Symposium Proceedings

|June 11, 2008

Summary

Progesterone receptors (PRA and PRB) are crucial for normal breast function but altered expression during carcinogenesis disrupts hormonal responses. Understanding these changes is vital for women

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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

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Last Updated: Jul 4, 2026

An Ex vivo Model to Study Hormone Action in the Human Breast

An Ex vivo Model to Study Hormone Action in the Human Breast

Published on: January 8, 2015

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

Area of Science:

Endocrinology
Molecular Biology
Oncology

Background:

Progesterone is vital for female reproduction, but progestins are linked to breast cancer development.
Progesterone's effects are mediated by PRA and PRB nuclear receptors, co-expressed in normal breast cells.
Disrupted PRA:PRB expression is observed early in breast carcinogenesis, leading to altered cellular functions.

Purpose of the Study:

To investigate the role of progesterone receptor isoforms (PRA and PRB) in breast cancer development.
To understand how unbalanced PRA and PRB expression affects hormonal response and gene regulation.
To explore the significance of progesterone receptor nuclear localization in breast carcinogenesis.

Main Methods:

Analysis of PRA and PRB expression patterns in normal and cancerous breast tissues.
Investigating the downstream effects of altered PRA:PRB ratios on gene expression.
Examining the dynamics of progesterone receptor nuclear translocation in breast cells.

Main Results:

Normal breast cells co-express PRA and PRB, but breast cancer shows disrupted, often predominant, expression of one isoform.
Unbalanced PRA:PRB expression leads to aberrant regulation of genes involved in cell morphology, actin cytoskeleton, and migration.
Altered nuclear localization of progesterone receptors (PR) is observed in cancer, potentially impacting gene expression and cell function.

Conclusions:

Disrupted progesterone receptor isoform balance is an early event in breast carcinogenesis.
Aberrant PR signaling due to unbalanced PRA:PRB expression contributes to malignant transformation.
Further research into progesterone action mechanisms in the breast is crucial given widespread progestin use.