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Related Experiment Videos

[Subacute arsenic poisoning].

M Ghariani1, M L Adrien, M Raucoules

  • 1Département d'Anesthésie-Réanimation, Hôpital Saint-Roch, Nice.

Annales Francaises D'Anesthesie Et De Reanimation
|January 1, 1991
PubMed
Summary
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A massive arsenic ingestion case highlights survival despite severe poisoning. The patient experienced gastrointestinal, neurological, and cardiac issues, with a fatal toxic cardiomyopathy.

Area of Science:

  • Toxicology
  • Cardiology
  • Neurology

Background:

  • This report details a rare case of acute arsenic poisoning from a massive voluntary ingestion of at least 8 grams.
  • The patient, a 23-year-old male, survived for 8 days despite the extreme dose, presenting with a complex array of symptoms.

Observation:

  • Predominant symptoms included severe gastrointestinal distress (nausea, vomiting, choleroid diarrhea), neurological deficits (encephalopathy, peripheral neuropathy), and cardiac abnormalities.
  • Metabolic acidosis, moderate cytolysis, and a significant anticoagulant effect were noted.
  • Postmortem findings revealed extensive tissue damage, including esophageal, gastric, hepatic, skin, and cardiac lesions, with arsenic detected in all examined tissues.

Findings:

  • The patient developed a fatal toxic cardiomyopathy, a severe cardiac complication of arsenic poisoning.

Related Experiment Videos

  • A unique circulating anticoagulant with prothrombinase activity and direct vitamin K antagonist effects contributed to the observed coagulopathy.
  • Histopathological examination confirmed widespread arsenic-induced organ damage.

    • Implications:

    • This case underscores the potential for severe, multi-organ toxicity from massive arsenic ingestion.
    • The identified anticoagulant mechanism provides insight into the hematological complications of arsenic poisoning.
    • Understanding these complex toxic effects is crucial for managing acute arsenic poisoning cases and improving patient outcomes.