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Related Experiment Video

Updated: Jul 4, 2026

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
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Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Published on: February 10, 2023

CD5-positive acute lymphoblastic leukemia.

Dawood Ahmed1, Tahir Aziz Ahmed, Suhaib Ahmed

  • 1Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|June 11, 2008
PubMed
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This case report details a rare CD5-positive B-cell Acute Lymphoblastic Leukemia (ALL) in a young woman. The diagnosis was confirmed by immunophenotyping and cytogenetic analysis revealed a t(9:22) translocation.

Area of Science:

  • Hematology
  • Oncology
  • Immunophenotyping

Background:

  • Acute Lymphoblastic Leukemia (ALL) is a heterogeneous group of lymphoid malignancies.
  • CD5-positive B-cell ALL is an exceptionally rare subtype, with limited documented cases.
  • Early identification and characterization are crucial for understanding disease biology and treatment.

Observation:

  • A young female patient presented with symptoms consistent with ALL.
  • Bone marrow examination confirmed the diagnosis of ALL (L-2).
  • Immunophenotyping revealed the leukemia cells to be CD5-positive B-cells.

Findings:

  • This represents the fourth reported case of CD5-positive B-cell ALL in the medical literature.
  • Cytogenetic analysis identified the specific translocation t(9;22), often associated with poor prognosis.

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Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

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Last Updated: Jul 4, 2026

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
06:08

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Published on: February 10, 2023

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Implications:

  • This case expands the understanding of rare ALL variants.
  • The presence of t(9;22) in CD5-positive B-cell ALL warrants further investigation into its prognostic significance.
  • Highlights the importance of comprehensive immunophenotyping and cytogenetic analysis in ALL diagnosis.