Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-Wide Analysis of Copy Number Variation in Vietnamese Local Chickens.

Animals : an open access journal from MDPI·2026
Same author

Winter Temperature Affects Fatty Acid Composition and Gene Expression, but Not Fat Content and Survival in a Northern Population of a Range-Expanding Spider.

Ecology and evolution·2025
Same author

Global Protein Profiling in Processed Immunohistochemistry Tissue Sections.

International journal of molecular sciences·2023
Same author

Identification of RELN variant p.(Ser2486Gly) in an Iranian family with ankylosing spondylitis; the first association of RELN and AS.

European journal of human genetics : EJHG·2020
Same author

Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort.

Biological psychiatry·2015
Same author

A t(3;9)(q25.1;q34.3) translocation leading to OLFM1 fusion transcripts in Gilles de la Tourette syndrome, OCD and ADHD.

Psychiatry research·2015
Same journal

Update on Genetic Chorea.

Current neurology and neuroscience reports·2026
Same journal

Gastrointestinal Dysfunction in Critically Ill Patients With Traumatic Brain Injury: Clinical Implications and Putative Mechanisms: a Narrative Review.

Current neurology and neuroscience reports·2026
Same journal

The Potential of Rehabilitation to Amplify Experience-Induced Myelin Plasticity and Remyelination in Multiple Sclerosis: A Narrative Review.

Current neurology and neuroscience reports·2026
Same journal

The Noradrenergic Brain in Parkinson's Disease.

Current neurology and neuroscience reports·2026
Same journal

Mapping the Silent Onset of Parkinson's Disease: Monoamine Imaging in the Era of the Race for Preclinical Intervention.

Current neurology and neuroscience reports·2026
Same journal

Functional and Structural Brain Imaging Correlates of Treatment Response in Functional Movement Disorder.

Current neurology and neuroscience reports·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2026

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

MicroRNAs in brain function and disease.

Andreas Walter Kuss1, Wei Chen

  • 1Department for Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Ihnestr. 73, D-14195, Berlin, Germany. kuss_a@molgen.mpg.de

Current Neurology and Neuroscience Reports
|June 11, 2008
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate gene expression and are vital for brain development and function. Dysregulation of miRNAs is linked to brain disorders, offering potential therapeutic targets.

More Related Videos

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

Related Experiment Videos

Last Updated: Jul 4, 2026

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small, non-coding RNA molecules regulating gene expression post-transcriptionally.
  • miRNAs are implicated in controlling a significant portion of protein-coding genes and cellular processes.
  • The role of miRNAs in the central nervous system is an area of intense research.

Purpose of the Study:

  • To review the role of the miRNA pathway in brain development, function, and disease.
  • To highlight miRNA-mediated gene regulation in key neuronal processes.
  • To discuss the therapeutic potential of miRNAs for neurological disorders.

Main Methods:

  • Literature review of recent observations on miRNA function in the brain.
  • Analysis of miRNA involvement in neuronal differentiation, synaptic plasticity, and circadian rhythms.
  • Discussion of etiological links between miRNAs and brain diseases.

Main Results:

  • miRNAs are crucial regulators of neuronal differentiation and synaptic plasticity.
  • The miRNA pathway significantly influences the brain's circadian clock.
  • Evidence suggests miRNAs are involved in the pathogenesis of various brain disorders.

Conclusions:

  • miRNAs are fundamental to normal brain function and development.
  • miRNA dysregulation contributes to the pathology of neurological diseases.
  • miRNAs represent a promising avenue for novel therapeutic strategies in neurology.