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Updated: Jul 4, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Cachexia: prevalence and impact in medicine.

Benjamin H L Tan¹, Kenneth C H Fearon

¹Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary, Edinburgh, UK.

Current Opinion in Clinical Nutrition and Metabolic Care

|June 11, 2008

Summary

Precachexia affects approximately 2% of the population with chronic diseases. Cachexia, though less common, significantly impacts patient survival and quality of life, posing a major public health concern.

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Last Updated: Jul 4, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Area of Science:

Gerontology
Internal Medicine
Clinical Nutrition

Background:

Cachexia is a complex condition characterized by progressive deterioration of body habitus.
It is frequently associated with chronic diseases like cancer, COPD, heart failure, and kidney disease.

Purpose of the Study:

To describe the prevalence and impact of cachexia and precachexia in patients with chronic diseases.
To highlight cachexia as a significant public health issue.

Main Methods:

Review of existing literature on cachexia and precachexia prevalence and impact.
Discussion of diagnostic challenges due to varied clinical presentations and definitions.

Main Results:

Estimating cachexia prevalence is difficult due to lack of a universal definition and masking by obesity.
Precachexia affects an estimated 2% of the population with chronic diseases.
A multidimensional assessment (weight loss, reduced intake, inflammation) is more clinically meaningful.

Conclusions:

Precachexia is highly prevalent in patients with chronic conditions.
While less frequent, the cachexia syndrome significantly increases morbidity and mortality.
Addressing cachexia is crucial for improving patient outcomes and quality of life.