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Related Experiment Video

Updated: Jul 4, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

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Published on: July 28, 2023

Gut-brain axis.

Johannes A Romijn¹, Eleonora P Corssmit, Louis M Havekes

¹Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands. j.a.romijn@lumc.nl

Current Opinion in Clinical Nutrition and Metabolic Care

|June 11, 2008

Summary

This summary is machine-generated.

The gut-brain axis influences satiety, metabolism, and bone health. Recent studies highlight the hypothalamus and gut peptides

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Area of Science:

Neurogastroenterology
Metabolic Research
Endocrinology

Background:

The gut-brain axis is a complex bidirectional communication system linking the gastrointestinal tract and the central nervous system.
Dysregulation of this axis is implicated in various metabolic disorders, including type 2 diabetes mellitus.
Gut peptides play crucial roles in regulating physiological processes.

Purpose of the Study:

To review and synthesize recent research on the regulation and functions of the gut-brain axis.
To explore the involvement of the hypothalamus and gut peptides in metabolic homeostasis and disease.

Main Methods:

Literature review of recent studies on the gut-brain axis.
Analysis of findings related to hypothalamic function, gut peptides, and neural pathways.
Synthesis of evidence linking the gut-brain axis to satiety, metabolism, and bone health.

Main Results:

Visual food cues and intake modulate the hypothalamus, with altered responses in type 2 diabetes.
Gut peptides regulate satiety, insulin secretion, and sensitivity; peptide YY also influences bone metabolism.
Afferent gastrointestinal nerves, particularly the vagal nerve, are increasingly recognized for their role in gut-brain axis modulation.

Conclusions:

The gut-brain axis is integral to numerous physiological functions, including satiety, food intake, and glucose/fat metabolism.
It also plays a role in insulin secretion/sensitivity and bone metabolism.
Further discoveries regarding the gut-brain axis are anticipated.