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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammation01:38

Inflammation

Overview
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

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Related Experiment Video

Updated: Jul 4, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

[Obesity as inflammatory disease].

Magdalena Olszanecka-Glinianowicz1, Barbara Zahorska-Markiewicz

  • 1Katedra Patofi zjologii Slaskiego Uniwersytetu Medycznego w Katowicach. magols@esculap.pl

Postepy Higieny I Medycyny Doswiadczalnej (Online)
|June 11, 2008
PubMed
Summary

Immune system activation in obesity is linked to insulin resistance, but may also be a protective homeostatic mechanism. This review explores immune activation, adipokines, and insulin resistance in obesity.

Area of Science:

  • Immunology
  • Metabolic Diseases
  • Adipose Tissue Biology

Context:

  • Obesity is a growing global health concern associated with numerous comorbidities.
  • Immune system activation is increasingly recognized as a key factor in obesity pathogenesis.
  • Recent research highlights a connection between immune activation in obesity and insulin resistance.

Purpose:

  • To review current literature on immune activation in obesity.
  • To examine the role of adipokines in obesity-related insulin resistance.
  • To explore the functional and gene expression similarities between adipocytes and macrophages.

Summary:

  • The review synthesizes findings on immune system activation in obesity and its link to insulin resistance.
  • It discusses the dual role of immune activation: potentially pathogenic and homeostatic.

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Last Updated: Jul 4, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Isolation of Adipose Tissue Immune Cells
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Isolation of Adipose Tissue Immune Cells

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An Acupoint Catgut-embedding Therapy for Treating Obesity
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An Acupoint Catgut-embedding Therapy for Treating Obesity

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  • The study highlights the involvement of adipokines and parallels between adipocytes and macrophages.

    • Impact:

    • Provides a comprehensive overview of immune system involvement in obesity and insulin resistance.
    • Offers insights into the complex relationship between adipose tissue, immune cells, and metabolic health.
    • Informs future research directions for understanding and treating obesity-related metabolic dysfunction.