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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

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Target selection: triage in the structural genomics battlefield.

James Raftery¹

¹School of Chemistry, The University of Manchester, Manchester, UK.

Methods in Molecular Biology (Clifton, N.J.)

|June 11, 2008

Summary

This study outlines methods for selecting protein targets for drug discovery, prioritizing unique and crystallizable proteins. Web resources aid in identifying novel targets from pathogen genomes like those causing tuberculosis and sleeping sickness.

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Area of Science:

Structural biology
Bioinformatics
Drug discovery

Background:

Protein target selection is crucial for developing new therapeutics.
Identifying novel, druggable protein targets remains a challenge in infectious disease research.

Purpose of the Study:

To present an approach for selecting protein targets for drug development.
To emphasize the use of web resources for identifying suitable protein targets.
To illustrate the methodology using examples from tuberculosis and sleeping sickness pathogens.

Main Methods:

Review of protein target selection strategies.
Utilizing web-based bioinformatics tools.
Genome analysis of selected pathogens.
Assessment of protein properties like orderliness and crystallizability.

Main Results:

A framework for selecting protein targets based on structural characteristics and novelty.
Identification of potential protein targets from tuberculosis and sleeping sickness pathogens.
Demonstration of how web resources can streamline target selection.

Conclusions:

Web resources are valuable for identifying well-ordered, crystallizable proteins that are distinct from existing structures.
This approach can accelerate the identification of novel drug targets for challenging diseases.