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Published on: January 30, 2018
Time-dependent behavioral recovery after sepsis in rats
Lisiane Tuon1, Clarissa M Comim, Fabricia Petronilho
1Laboratório de Neurociências, Programa de Pós-Graduação Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil.
Intensive Care Medicine
|June 11, 2008
Summary
Sepsis survivors showed cognitive deficits in memory and learning 10 and 30 days after cecal ligation and puncture (CLP). These sepsis-induced cognitive impairments fully resolved by 60 days post-CLP.
Area of Science:
- Neuroscience
- Sepsis Research
- Animal Models
Background:
- Sepsis can lead to long-term neurological complications, including cognitive dysfunction.
- Understanding the temporal dynamics of sepsis-induced cognitive deficits is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the long-term cognitive performance of rats surviving sepsis induced by cecal ligation and puncture (CLP).
- To determine the time course of cognitive recovery after sepsis.
Main Methods:
- Male Wistar rats underwent either sham surgery or CLP to induce sepsis.
- Survivors were assessed using six behavioral tasks at 10, 30, and 60 days post-surgery.
- Tasks included open field habituation, inhibitory avoidance, object recognition, and forced swimming tests.
Main Results:
- Sepsis survivors exhibited significant cognitive deficits in learning and memory at 10 and 30 days post-CLP.
- Deficits were observed in tasks such as object recognition, inhibitory avoidance, and open field habituation.
- All measured cognitive impairments were reversed by 60 days after sepsis induction.
Conclusions:
- Cognitive impairments following sepsis are persistent, lasting at least 30 days.
- The resolution of cognitive deficits by 60 days suggests a potential for recovery.
- This sepsis model provides insights into the biological mechanisms underlying sepsis-induced behavioral changes.
