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Updated: Jul 4, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
[Lung cancer, smoking and genetic modifications]
1Spitalul Clinic Fundeni, Secţia clinică de radiobiologie. popdociul@yahoo.com
Abstract:
Lung cancer represents a heterogeneity entity consisting of different histopathologic, clinic and therapeutic subtypes. Smoking is the most well-known risk factor, but the mechanisms of occurrence of lung cancer are not completely understood yet. The effects of smoking are related to the young age of beginning of smoking, the daily dose and the length of smoking, but they also depend of the individual heredity due to the gene polymorphism. Smoking induces several deleterious mechanisms: inactivation of tumor-suppressor genes, activation of proto-oncogenes, increase in telomerase's activity.
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