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Updated: Jul 4, 2026

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits
Published on: January 8, 2020
[Changes in lacrimal secretion in rabbits according to meibomian glands activity]
Cristina Stan1, Oana Visan, O Samoila
1Clinica Oftalmologica UMF Iuliu Hatieganu, Cluj-Napoca.
Purpose:
The purpose of this issue is to create an experimental animal model of dry eye and study the alteration of lachrymal secretion in time.
Materials And Methods:
We used a group of 8 rabbits in which the Meibomian gland orifices of the right eye were individually closed by cauterization, the results being related to the sound left eye.
Results:
We studied: the quantitative alteration of the lachrymal secretion using Schirmer 1 test; the alteration of lachrymal film using rose-bengal and fluorescein staining; the variation in tear protein concentration and histopathological changes in conjunctiva.
Conclusions:
We found histopathological changes in conjunctiva and in the lachrymal secretion consisting in conjunctival goblet-ceil density decrease and watery secretion increase, probably due to lachrymal viscosity decrease mechanism.
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