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Updated: Jul 4, 2026

Cell Population Analyses During Skin Carcinogenesis

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Basal cell carcinomas arising within multiple trichoepitheliomas.

Laura B Pincus¹, Timothy H McCalmont, Isaac M Neuhaus

¹Department of Dermatology, University of California San Francisco, San Francisco, CA, USA. pincusl@derm.ucsf.edu

Journal of Cutaneous Pathology

|June 12, 2008

Summary

This summary is machine-generated.

Multiple familial trichoepitheliomas (MFT) can develop secondary basal cell carcinomas (BCCs). This highlights the importance of monitoring MFT patients for potential evolution of malignancy.

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Area of Science:

Dermatology
Oncology
Genetics

Background:

Multiple familial trichoepitheliomas (MFT) are typically considered benign follicular tumors.
The natural history and malignant potential of MFT have remained largely undefined.

Observation:

A 57-year-old male presented with numerous, long-standing facial papules and plaques consistent with MFT.
Some lesions exhibited recent enlargement and ulceration, with similar family history.
Biopsies revealed trichoepitheliomas (TEs) co-existing with basal cell carcinoma (BCC) in the same tissue sections.

Findings:

The co-occurrence of TEs and BCCs suggests secondary development of BCCs within MFT lesions.
This challenges previous assumptions and necessitates re-evaluation of prior MFT-associated BCC diagnoses.
The study provides compelling evidence for the evolution of malignancy within MFT.

Implications:

Increased awareness of secondary carcinomatous change in MFT is crucial for patient management.
Regular monitoring and early detection of BCCs in MFT patients are recommended.
This research refines understanding of MFT natural history and its association with skin cancer.