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Continuous rise in incidence of childhood Type 1 diabetes in Germany
S Ehehalt1, G Blumenstock, A M Willasch
1University Children's Hospital, Eberhard-Karls-University, Tübingen, Germany.
Insights
The incidence of Type 1 diabetes (T1DM) in children and adolescents in Germany is rising faster than expected. This trend shows a concerning shift towards younger children being diagnosed with T1DM.
Area of Science:
- Pediatric Endocrinology
- Epidemiology
- Public Health
Background:
- Type 1 diabetes (T1DM) is a significant chronic condition in children and adolescents.
- Understanding incidence trends is crucial for public health planning and resource allocation.
Purpose of the Study:
- To assess the incidence rate and identify trends in Type 1 diabetes (T1DM) among individuals under 15 years of age in Baden-Württemberg, Germany.
- To analyze age-specific incidence patterns and changes over time.
Main Methods:
- A population-based registry study was conducted in Baden-Württemberg, Germany, covering all 31 pediatric departments and one diabetes center.
- Case ascertainment followed EURODIAB criteria with a high degree of completeness (97.2%).
- Data collection spanned from 1987 to 2003.
Main Results:
- The age- and sex-standardized incidence rate of T1DM was 14.1 per 100,000 person-years.
- An estimated annual increase in incidence of 3.8% was observed, with the number of new cases doubling between 1987-1989 and 2000-2003.
- The highest incidence rise was noted in the youngest age group (0-4 years), indicating a shift towards earlier onset.
Conclusions:
- The incidence of new-onset Type 1 diabetes (T1DM) in German children and adolescents is increasing at an accelerated rate.
- A notable trend shows a shift in the age of onset towards younger children.
Aims:
To assess the incidence and the trend in incidence of Type 1 diabetes (T1DM) in children and adolescents < 15 years of age in Baden-Württemberg (BW), Germany.
Methods:
BW is Germany's third largest federal state. All 31 paediatric departments in BW and one diabetes centre participated in the study. Case registration was done according to the EURODIAB criteria. The degree of ascertainment was 97.2%.
Results:
From 1987 to 2003, the age- and sex-standardized incidence rate was 14.1/100,000 per year [95% confidence interval (CI) 13.7, 14.6, n = 4017]. The estimated annual increase in incidence was 3.8% (95% CI 1.1, 6.6). Compared with the first years of our registry, the current mean number of new cases of T1DM has doubled (1987-1989, n = 153; 2000-2003, n = 302). Generally, the highest rise in incidence occurred in the youngest age group of 0-4-year-old patients (5.8%; 95% CI 2.5, 9.3), followed by the age groups 5-9 (3.4%; 95% CI 0.8, 6.0) and 10-14 (2.7%; 95% CI 0.3, 5.1).
Conclusions:
In Germany, the number of children and adolescents with new-onset T1DM has been rising at a faster pace than expected. A distinct shift to younger age at onset has been observed in Germany.
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