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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Updated: Jul 4, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

Transfusion-associated graft-versus-host disease.

D M Dwyre1, P V Holland

  • 1Department of Pathology, University of California Davis Medical Center, Sacramento, CA 95817, USA. denis.dwyre@ucdmc.ucdavis.edu

Vox Sanguinis
|June 12, 2008
PubMed
Summary
This summary is machine-generated.

Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare, fatal complication caused by transfused T lymphocytes attacking the host. Prevention through blood irradiation is crucial for susceptible patients.

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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

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Last Updated: Jul 4, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Area of Science:

  • Hematology
  • Immunology
  • Transfusion Medicine

Background:

  • Transfusion-associated graft-versus-host disease (TA-GvHD) is a severe complication following blood transfusions.
  • It results from transfused T lymphocytes attacking host tissues, leading to bone marrow aplasia and rapid fatality.

Purpose of the Study:

  • To describe the pathophysiology, clinical presentation, and management of TA-GvHD.
  • To emphasize the importance of prevention strategies in mitigating this rare but devastating condition.

Main Methods:

  • Review of existing literature on TA-GvHD.
  • Analysis of the immunological mechanisms underlying TA-GvHD.
  • Discussion of current and emerging prevention methods.

Main Results:

  • TA-GvHD is caused by alloreactive T lymphocytes surviving host immune responses due to HLA similarity and immunosuppression.
  • Fresh blood components pose a higher risk due to intact T lymphocytes.
  • Current treatments are largely ineffective.

Conclusions:

  • Prevention, primarily through irradiation of blood products for at-risk individuals, is the most effective strategy against TA-GvHD.
  • Pathogen inactivation technologies may offer future preventative benefits.