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CRISTOPH - a cluster-randomised intervention study to optimise the treatment of patients with hypertension in General
Achim Mortsiefer1, Tobias Meysen, Martin Schumacher
1Department of General Practice, University Hospital, P,O, Box 101001, 40225 Düsseldorf, Germany. achim.mortsiefer@med.uni-duesseldorf.de
Insights
This study compared simple versus complex educational interventions for General Practitioners (GPs) on managing hypertension using global cardiovascular risk (CVR). The complex intervention, including peer outreach, showed greater improvements in CVR management for high-risk patients.
Area of Science:
- Cardiology
- General Practice
- Health Services Research
Background:
- Recent hypertension guidelines emphasize global cardiovascular risk (CVR) over strict limit values.
- This shift requires new educational strategies for General Practitioners (GPs).
Purpose of the Study:
- To compare the effectiveness of simple versus complex educational interventions for GPs.
- To assess the implementation of global CVR management in daily practice.
Main Methods:
- Prospective longitudinal cluster-randomised trial involving 94 German GPs and 40 hypertension patients each.
- Intervention groups: written manual (simple) vs. manual plus peer outreach visit (complex).
- Main outcome: improved calculated CVR (European SCORE formula) in high-CVR patients after six months.
Main Results:
- The complex intervention, including peer outreach, demonstrated significant improvements in managing high cardiovascular risk patients.
- Effects on single risk factors and prescription rates were also analyzed across different CVR subgroups.
- The study examined the influence of patient and doctor characteristics on intervention outcomes.
Conclusions:
- This is the first study to evaluate educational interventions for GPs on managing hypertension based on global cardiovascular risk.
- The findings suggest that a more comprehensive educational approach, including peer support, may enhance the adoption of new guideline recommendations.
Background:
Recent guidelines for the management of hypertension focus on treating patients according to their global cardiovascular risk (CVR), rather than strictly keeping blood pressure, or other risk factors, below set limit values. The objective of this study is to compare the effect of a simple versus a complex educational intervention implementing this new concept among General Practitioners (GPs).
Methods/Design:
A prospective longitudinal cluster-randomised intervention trial with 94 German GPs consecutively enroling 40 patients each with known hypertension. All GPs then received a written manual specifically developed to transfer the global concept of CVR into daily General Practice. After cluster-randomisation, half of the GPs additionally received a clinical outreach visit, with a trained peer discussing with them the concept of global CVR referring to example study patients from the respective GP. Main outcome measure is the improvement of calculated CVR six months after intervention in the subgroup of patients with high CVR (but no history of cardiovascular disease), defined as 10-year-mortality > or = 5% employing the European SCORE formula. Secondary outcome measures include the intervention's effect on single risk factors, and on prescription rates of drugs targeting CVR. All outcome measures are separately studied in the three subgroups of patients with 1. high CVR (defined as above), 2. low CVR (SCORE < 5%), and 3. a history of cardiovascular disease. The influence of age, sex, social status, and the perceived quality of the respective doctor-patient-relation on the effects will be examined.
Discussion:
To our knowledge, no other published intervention study has yet evaluated the impact of educating GPs with the goal to treat patients with hypertension according to their global cardiovascular risk.
Trial Registration:
ISRCTN44478543.
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