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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Gene amplification is a poor prognostic factor in anaplastic oligodendrogliomas
Ahmed Idbaih1, Emmanuelle Crinière, Yannick Marie
1Institut National de la Santé et de la Recherche Médicale, U711, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, Paris, France. ahmed.idbaih@gmail.com
Neuro-Oncology
|June 12, 2008
Summary
Gene amplification in anaplastic oligodendrogliomas is common and linked to poorer survival. This study reveals gene amplification is exclusive of 1p/19q codeletion, offering new prognostic insights.
Area of Science:
- Neuro-oncology
- Genomics
- Cancer research
Background:
- Gene amplifications are observed in gliomas, but comprehensive prognostic-genomic correlations are lacking for anaplastic oligodendrogliomas.
- Investigating simultaneous amplification of multiple genes is crucial for understanding tumor progression.
Purpose of the Study:
- To investigate the frequency and prognostic significance of gene amplifications in anaplastic oligodendrogliomas.
- To explore the correlation between gene amplification and 1p/19q codeletion status.
Main Methods:
- Bacterial artificial chromosome-array based comparative genomic hybridization (BAC-array CGH) and quantitative polymerase chain reaction (qPCR) were used.
- A set of 38 previously reported amplified genes in gliomas were analyzed in 52 anaplastic oligodendroglioma samples.
Main Results:
- Fifteen out of 38 target genes were amplified in at least one tumor; 27% of anaplastic oligodendrogliomas showed gene amplification.
- Epidermal growth factor receptor (EGFR) and cyclin-dependent kinase 4/sarcoma amplified sequence (CDK4/SAS) were the most frequent amplifications.
- Gene amplification was mutually exclusive with 1p/19q codeletion (p = 0.005).
Conclusions:
- Gene amplification is a significant negative prognostic factor for progression-free and overall survival in anaplastic oligodendrogliomas.
- Gene amplification provides complementary prognostic information beyond established factors like extent of surgery, KPS, and 1p/19q status.
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