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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: Jul 4, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

MicroRNA and cardiac pathologies.

Michael V G Latronico1, Daniele Catalucci, Gianluigi Condorelli

  • 1Laboratory of Genetic and Molecular Cardiology, Science and Technology Pole, Istituto di Ricovero e Cura a Carattere Scientifico MultiMedica, Milan, Italy.

Physiological Genomics
|June 12, 2008
PubMed
Summary

MicroRNAs are crucial for heart development and function. Dysregulation of these small molecules is linked to various heart diseases and congenital anomalies, as detailed in recent findings.

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Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Related Experiment Videos

Last Updated: Jul 4, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Area of Science:

  • Cardiovascular Biology
  • Molecular Genetics
  • Developmental Biology

Background:

  • MicroRNAs play vital roles in cardiovascular development and physiology.
  • Specific microRNAs are implicated in heart disease pathogenesis, including chamber morphogenesis, conduction, and contraction.
  • MicroRNA expression signatures correlate with pathological cardiac phenotypes like hypertrophy and cardiomyopathy.

Purpose of the Study:

  • To summarize the latest research on microRNAs in cardiovascular health and disease.
  • To highlight the association between microRNA dysregulation and congenital heart anomalies.
  • To provide an overview of current findings in the field.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of studies linking microRNAs to cardiovascular pathogenesis.
  • Examination of data on microRNA expression in cardiac conditions.

Main Results:

  • MicroRNAs are essential for normal cardiovascular development and function.
  • Specific microRNAs are involved in key processes like chamber morphogenesis, conduction, and contraction.
  • Altered microRNA expression is associated with various cardiac pathologies, including hypertrophy, ischemic and dilated cardiomyopathy, and aortic stenosis.
  • MicroRNA dysregulation may contribute to congenital heart anomalies.

Conclusions:

  • MicroRNAs are critical regulators of cardiovascular physiology and development.
  • Aberrant microRNA expression is a significant factor in the pathogenesis of numerous cardiovascular diseases.
  • Further research into microRNAs offers potential for understanding and treating congenital heart defects and acquired cardiac conditions.