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Related Experiment Video

Updated: Jul 4, 2026

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
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Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma

Published on: November 11, 2021

SCT for Wilms' tumour.

S Dallorso1, G Dini, M Faraci

  • 1Istituto di Ricovero e Cura a Carattere Scientifico, Genoa, Italy. sandrodallorso@ospedale-gaslini.ge.it

Bone Marrow Transplantation
|July 24, 2008
PubMed
Summary
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Wilms

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Stem Cell Transplantation

Background:

  • Wilms' tumour has a high cure rate (85-90%) with initial treatment.
  • Relapsed Wilms' tumour has a significantly lower success rate (25-45%).
  • Identifying prognostic factors aids in selecting patients for intensive relapse therapy.

Purpose of the Study:

  • To review re-induction strategies for relapsed Wilms' tumour.
  • To discuss the role of high-dose chemotherapy (HCT) with autologous stem cell rescue.
  • To analyze data from transplant databases and literature for treatment insights.

Main Methods:

  • Review of European Group for Blood and Marrow Transplantation (EBMT) database (>300 transplants).
  • Analysis of published literature on rescue therapy and HCT for relapsed Wilms' tumour.

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  • Discussion of ongoing treatment proposals from European and US cooperative groups.

    • Main Results:

    • High-dose chemotherapy (HCT) followed by autologous hematopoietic stem cell rescue shows promising results in small patient cohorts.
    • Data from over 300 transplants in the EBMT database provide insights into HCT efficacy.
    • Several adverse prognostic factors are identified for patients with relapsed Wilms' tumour.

    Conclusions:

    • High-dose chemotherapy (HCT) with autologous stem cell rescue is a viable option for relapsed Wilms' tumour.
    • Further research and discussion within cooperative groups are ongoing for optimizing treatment protocols.
    • Understanding prognostic factors is crucial for tailoring intensive therapies for relapsed cases.