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Updated: Jul 4, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
Published on: March 22, 2012
Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
Stefan Schütze1, Vladimir Tchikov, Wulf Schneider-Brachert
1Institute of Immunology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany. schuetze@immunologie.uni-kiel.de
Abstract:
The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-kappaB (NF-kappaB) or through activation of the proliferative mitogen-activated protein kinase (MAPK) cascade. Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell.
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