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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Aspergillus niger causing tracheobronchitis and invasive pulmonary aspergillosis in a lung transplant recipient: case

Melissa Orzechowski Xavier1, Maria da Penha Uchoa Sales, José de Jesus Peixoto Camargo

  • 1Universidade Federal do Rio Grande do Sul, Porto Alegre, RS.

Revista Da Sociedade Brasileira De Medicina Tropical
|June 12, 2008
PubMed

Insights

Invasive aspergillosis caused by Aspergillus niger occurred in a lung transplant patient with hyperglycemia and cytomegalovirus infection. This highlights Aspergillus niger

Area of Science:

  • Medical Mycology
  • Transplant Surgery
  • Immunocompromised Hosts

Background:

  • Lung transplant recipients are susceptible to opportunistic infections.
  • Invasive aspergillosis poses a significant threat in immunocompromised individuals.
  • Aspergillus niger is typically considered a low-virulence fungal species.

Observation:

  • A lung transplant recipient developed invasive aspergillosis caused by Aspergillus niger.
  • The patient experienced postoperative hyperglycemia.
  • Cytomegalovirus infection was another complication observed in the patient.

Findings:

  • Aspergillus niger demonstrated invasive potential in a severely immunosuppressed host.
  • Hyperglycemia and cytomegalovirus infection were associated conditions.
  • The case underscores the importance of vigilance for fungal infections post-transplant.

Implications:

  • Severely immunocompromised states are critical for Aspergillus niger pathogenesis.
  • Early detection and management of fungal infections are vital in transplant care.
  • This case expands understanding of Aspergillus niger virulence factors in clinical settings.

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