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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Published on: June 2, 2014

Migraine: a genetic disease?

Pasquale Montagna¹

¹Department of Neurological Sciences, University of Bologna Medical School, Via U. Foscolo 7, 40123 Bologna, Italy. pasquale.montagna@unibo.it

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|July 17, 2008

Summary

This summary is machine-generated.

Migraine genetics are complex. Familial hemiplegic migraine (FHM) genes aren't linked to typical migraines (MA/MO), suggesting FHM is distinct and epigenetics may influence common migraine types.

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Area of Science:

Neuroscience
Genetics
Evolutionary Biology

Background:

Migraines, including migraine with aura (MA) and migraine without aura (MO), have a significant genetic component.
Linkage to chromosomal loci has been identified for typical migraines, but no specific genes are known.
Genes identified for familial hemiplegic migraine (FHM) are not implicated in typical MA/MO.

Purpose of the Study:

To differentiate familial hemiplegic migraine (FHM) from typical migraines (MA/MO).
To propose the involvement of epigenetic mechanisms in the development of typical migraines.
To present primary headaches as conserved, adaptive behavioral responses signaling homeostatic imbalance.

Main Methods:

Review of existing genetic linkage data for typical migraines and FHM.
Comparative analysis of genetic factors between FHM and MA/MO.
Theoretical modeling integrating epigenetic factors and behavioral responses in headache genetics.

Main Results:

Genes for FHM are not associated with typical MA/MO.
FHM should be classified as a syndromic migraine, separate from MA.
Epigenetic mechanisms and a genetic behavioral model are proposed for typical migraines.

Conclusions:

The genetic basis of FHM differs from typical migraines (MA/MO).
Epigenetic factors likely contribute to the etiology of common migraine types.
Headaches may represent evolutionarily conserved adaptive responses to homeostatic disruption.