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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Antibiotic stewardship through the EU project "ABS International"
Franz Allerberger1, Annegret Frank, Roland Gareis
1Roland Gareis Consulting, Osterreichische Agentur für Gesundheit und Ernährungssicherheit (AGES), Wien, Austria. franz.allerberger@ages.at
Antimicrobial resistance necessitates antibiotic stewardship (ABS) programs. The ABS International project developed training and tools for appropriate antibiotic use in European hospitals, with future programs needing public and primary care integration.
Area of Science:
- Infectious Diseases
- Public Health
- Healthcare Management
Background:
- Antimicrobial resistance (AMR) is a growing global health threat.
- Effective antibiotic stewardship (ABS) programs are crucial for combating AMR.
- Previous efforts have focused on hospital settings, highlighting a need for broader implementation.
Purpose of the Study:
- To implement and evaluate antibiotic stewardship strategies across multiple European Union member states.
- To develop standardized ABS tools and training programs for healthcare professionals.
- To assess the feasibility and impact of ABS implementation in diverse healthcare settings.
Main Methods:
- Development of a comprehensive training program for national ABS trainers.
- Creation of standardized ABS tools, including antibiotic lists, treatment guidelines, and organizational templates.
- Implementation of ABS tools in up to five healthcare facilities per participating country.
- Establishment of process measures and quality indicators for monitoring antibiotic use.
Main Results:
- Successful development and dissemination of training programs and standardized ABS tools.
- Initiation of ABS tool implementation in numerous healthcare facilities across nine EU countries.
- Establishment of a framework for measuring the quality of antibiotic use.
Conclusions:
- The ABS International project provides a scalable model for implementing antibiotic stewardship in hospitals.
- Future antimicrobial stewardship initiatives must extend to public education and primary care settings.
- Continued efforts in ABS are essential to mitigate the threat of antimicrobial resistance.
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