Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thrombolytic therapy for stroke.

T Brott1

  • 1Department of Neurology, University of Cincinnati College of Medicine, OH 45267-0525.

Cerebrovascular and Brain Metabolism Reviews
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ischaemic stroke.

European journal of neurology·2017
Same author

Early treatment of acute ischemic stroke.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Silent cerebral infarction/lacunes.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Use of Ephedra-containing products and risk for hemorrhagic stroke.

Neurology·2003
Same author

Thrombolysis in patients with transient neurologic deficits.

Neurology·2001
Same author

Apolipoprotein E phenotype and the efficacy of intravenous tissue plasminogen activator in acute ischemic stroke.

Annals of neurology·2001
Same journal

Cerebrovascular reactivity: role of endothelium/platelet/leukocyte interactions.

Cerebrovascular and brain metabolism reviews·1996
Same journal

Neuroimaging for differentiating vascular from Alzheimer's dementias.

Cerebrovascular and brain metabolism reviews·1996
Same journal

Opiate receptor-mediated mechanisms in the regulation of cerebral blood flow.

Cerebrovascular and brain metabolism reviews·1996
Same journal

Vascular dementia: a construct in evolution.

Cerebrovascular and brain metabolism reviews·1996
Same journal

Multimodal monitoring and assessment of cerebral haemodynamic reserve after severe head injury.

Cerebrovascular and brain metabolism reviews·1996
Same journal

Cortical thermal clearance as a predictor of imminent neurological deterioration.

Cerebrovascular and brain metabolism reviews·1996
See all related articles

Thrombolytic therapy shows promise for stroke treatment, achieving vascular recanalization in patients. However, clinical benefits are not yet established, and brain hemorrhage remains a concern.

Area of Science:

  • Neurology
  • Cardiology
  • Hematology

Background:

  • Thrombolytic therapy is beneficial for acute myocardial infarction and has shown success in vascular recanalization for stroke.
  • Advances in fibrinolytic system understanding have spurred novel thrombolytic strategies.
  • Animal stroke studies demonstrate promising arterial recanalization and safety profiles.

Purpose of the Study:

  • To review the current status and potential of thrombolytic therapy in stroke treatment.
  • To assess the efficacy and safety of thrombolytic agents in achieving vascular recanalization.
  • To explore the application of thrombolysis in various hemorrhagic stroke types.

Main Methods:

  • Review of recent advancements in thrombolytic strategies and fibrinolytic system.

Related Experiment Videos

  • Analysis of animal studies focusing on arterial recanalization and safety in stroke models.
  • Evaluation of clinical pilot studies utilizing brain computed tomography for patient selection in nonhemorrhagic stroke.
  • Assessment of demonstrated arterial recanalization in ischemic stroke patients treated with thrombolytic drugs.

    • Main Results:

    • Arterial recanalization achieved in patients with ischemic stroke using various thrombolytic drugs.
    • Brain hemorrhage identified as an infrequent but serious complication, associated with high morbidity and mortality.
    • Limited human studies for hemorrhagic stroke types show modest complications and encouraging clinical outcomes.

    Conclusions:

    • Thrombolytic therapy has demonstrated arterial recanalization in ischemic stroke, but clinical benefit requires placebo-controlled trials.
    • While brain hemorrhage is a concern, thrombolytic therapy may offer future treatment potential for subarachnoid and intracerebral hemorrhage.
    • Further research is needed to establish clinical efficacy and optimize safety for thrombolytic treatment in diverse stroke types.