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Efficiency of the cyclic batch antibiotic fermentation.

R Guthke¹, W A Knorre

¹Central Institute of Microbiology and Experimental Therapy, Academy of Sciences of the German Democratic Republic, 6900 Jena, German Democratic Republic.

Biotechnology and Bioengineering

|October 1, 1982

Summary

Cyclic batch cultivation can outperform chemostat methods for microbial product formation. This is especially true when considering substrate inhibition and age-dependent productivity loss in the mathematical model.

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Area of Science:

Biotechnology
Microbial Physiology
Biochemical Engineering

Background:

Microbial product formation is crucial for various industries.
Optimizing cultivation methods is key to maximizing product yield.
Understanding factors like substrate inhibition and culture age is vital for productivity.

Purpose of the Study:

To compare the productivities of stationary and nonstationary microbial cultivation methods.
To identify conditions under which cyclic batch cultivation is superior to chemostat cultivation.
To develop a mathematical model incorporating substrate inhibition and age-dependent productivity loss.

Main Methods:

Development of a simple mathematical model for microbial product formation.
Comparative analysis of chemostat (continuous) and cyclic batch (nonstationary) cultivation strategies.
Inclusion of substrate inhibition and age-dependent productivity loss within the model.

Main Results:

The mathematical model quantifies productivity differences between cultivation methods.
Conditions favoring cyclic batch cultivation over chemostat methods were identified.
Substrate inhibition and culture age significantly impact overall productivity.

Conclusions:

Cyclic batch cultivation offers advantages for microbial product formation under specific conditions.
The developed model provides insights into optimizing bioprocesses by accounting for key inhibitory factors.
Further research can refine these models for enhanced industrial applications.