Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug-target interactions: only the first step in the commitment to a programmed cell death?

C Dive1, J A Hickman

  • 1Toxicology Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, UK.

British Journal of Cancer
|July 1, 1991
PubMed
Summary

Novel antitumour drug discovery faces challenges due to cancer cell resistance. Understanding cell death mechanisms, rather than just drug action, may unlock more effective chemotherapy strategies by targeting cellular responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune biomarker evaluation of sequential tyrosine kinase inhibitor and nivolumab monotherapies in renal cell carcinoma: the phase I TRIBE trial.

Immuno-oncology technology·2024
Same author

Plasma Tie2 trajectories identify vascular response criteria for VEGF inhibitors across advanced biliary tract, colorectal and ovarian cancers.

ESMO open·2022
Same author

iRFP (near-infrared fluorescent protein) imaging of subcutaneous and deep tissue tumours in mice highlights differences between imaging platforms.

Cancer cell international·2021
Same author

Erratum to 'Longitudinal characterisation of haematological and biochemical parameters in cancer patients prior to and during COVID-19 reveals features associated with outcome': [ESMO Open Volume 6, Issue 1, February 2021, 100005].

ESMO open·2021
Same author

Longitudinal characterisation of haematological and biochemical parameters in cancer patients prior to and during COVID-19 reveals features associated with outcome.

ESMO open·2021
Same author

How liquid biopsies can change clinical practice in oncology.

Annals of oncology : official journal of the European Society for Medical Oncology·2019

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Antitumour drug development has plateaued, with carcinomas remaining highly resistant to current therapies.
  • Overcoming drug resistance is critical for advancing cancer treatment, necessitating a deeper understanding of cellular sensitivity and resistance mechanisms.

Purpose of the Study:

  • To review recent literature on cell death mechanisms in cancer.
  • To explore the hypothesis that cell response to drug-target interactions, not just drug biochemistry, dictates chemotherapy outcomes.

Main Methods:

  • Literature review of recent research on cell death.
  • Analysis of the role of cellular phenotype in response to chemotherapy.

Main Results:

Related Experiment Videos

  • Chemotherapy effectiveness may depend on the cell's reaction to the drug-target complex and subsequent events.
  • Cellular phenotype influences the activation of programmed cell death pathways in response to treatment.

Conclusions:

  • Rethinking chemotherapy's mechanism of action to include cellular response pathways is crucial for improving antitumour drug efficacy.
  • Targeting programmed cell death offers a promising avenue for overcoming cancer drug resistance.