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Related Experiment Videos

Ethanol production by extractive fermentation.

M Minier1, G Goma

  • 1Départment de Génie Biochimique et Alimentaire, ERA-CNRS No. 879. INSA, Avenue de Rangueil, F-31077 Toulouse Cédex, France.

Biotechnology and Bioengineering
|July 1, 1982
PubMed
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Extractive fermentation removes inhibitory metabolites during ethanol production using 1-dodecanol. This novel pulsed packed column reactor enhances glucose utilization and cell growth for industrial applications.

Area of Science:

  • Biochemical Engineering
  • Industrial Biotechnology

Background:

  • Cell growth and production are often inhibited by accumulating terminal metabolites.
  • Efficient removal of these inhibitors is crucial for optimizing fermentation processes.

Purpose of the Study:

  • To demonstrate the feasibility of extractive fermentation for enhanced ethanol production.
  • To evaluate a novel pulsed packed column reactor for this process.

Main Methods:

  • Coupling fermentation with liquid-liquid extraction using 1-dodecanol as the solvent.
  • Utilizing a pneumatically pulsed packed column reactor with cell-adsorbing porous material.
  • Investigating the inhibitory effects of aliphatic alcohols on yeast growth.

Main Results:

Related Experiment Videos

  • 1-dodecanol effectively extracts inhibitory metabolites, allowing for higher substrate concentrations (409 g/L glucose).
  • The pulsed packed column reactor improved interfacial area and reduced gas holdup.
  • Yeast demonstrated complete glucose utilization, surpassing limitations of classical fermentation.

Conclusions:

  • Extractive fermentation is a viable strategy for overcoming metabolite inhibition in bioproduction.
  • The developed reactor system significantly enhances fermentation efficiency and substrate utilization.
  • This method holds potential for various microbial production processes inhibited by excreted metabolites.