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Updated: Jul 4, 2026

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
Published on: August 2, 2018
[C1772T polymorphism of hypoxia-inducible factor-1 alpha gene in Han ethnic population from Northern China]
Hai-Ping Liu1, Yang Xu, Chun-Yan Jin
1Department of Sports and Human Science, Wenzhou Medical College, Wenzhou 325035, China. liuhaip@126.com
Objective:
To analyze the distribution of single nucleotide polymorphism C1772T (SNP/C1772T) in hypoxia-inducible factor -1 alpha (HIF-1 alpha) gene in Han ethnic population from Northern China.
Methods:
Allele frequencies in a sample of 206 healthy Chinese Hans were determined by polymerase chain reaction followed by restriction fragment length polymorphism.
Result:
The genotype frequencies of C1772T observed in Chinese Hans were 93 % and 7% for CC and CT respectively; and allele frequencies were 96% and 4 %for C and T respectively. There was significant difference in distribution of allele frequencies between Chinese Hans and Caucasian.
Conclusion:
The single nucleotide polymorphism of C1772T in HIF-1 alpha gene has difference in different ethnic population.
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