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Updated: Jul 4, 2026

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
08:07

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

[PI3K-AKT network roles in infectious diseases]

Masayuki Noguchi1, Keiichi Kinowaki

  • 1Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University.

Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
|June 13, 2008
PubMed

Insights

The PI3K-AKT pathway regulates cell functions and is implicated in diseases like cancer and diabetes. Suppressing this pathway may offer a novel strategy against viral infections and prevent malignant transformation.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Oncology

Context:

  • The Phosphatidylinositol 3-Kinase-Protein Kinase B (PI3K-AKT) network is a critical intracellular signaling pathway.
  • It is activated by cytokines and growth factors, regulating vital cellular processes.
  • Dysregulation of this network is linked to various diseases, including cancer and diabetes mellitus.

Purpose:

  • To review the role of the PI3K-AKT network in cellular responses.
  • To explore its involvement in pathological viral and bacterial infections.
  • To discuss potential therapeutic strategies targeting this network.

Summary:

  • The PI3K-AKT pathway controls cell proliferation, survival, metabolism, and more.
  • Genomic alterations in this network contribute to cancer and other diseases.
  • It also plays a role in viral infections, including Epstein-Barr, hepatitis C, hepatitis B, and HIV, influencing latent, chronic, and malignant stages.
  • The network's involvement extends to tumorigenic viral infections, affecting malignant transformation.

Impact:

  • Understanding the PI3K-AKT network's role in disease is crucial for developing new treatments.
  • Targeting the PI3K-AKT pathway offers a potential strategy for antiviral therapies.
  • Inhibiting PI3K-AKT activity may prevent malignant transformation associated with tumorigenic viral infections.

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