[PI3K-AKT network roles in infectious diseases]
Masayuki Noguchi1, Keiichi Kinowaki
1Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University.
Summary
The PI3K-AKT pathway regulates cell functions and is implicated in diseases like cancer and diabetes. Suppressing this pathway may offer a novel strategy against viral infections and prevent malignant transformation.
Area of Science:
- Molecular Biology
- Cellular Signaling
- Oncology
Context:
- The Phosphatidylinositol 3-Kinase-Protein Kinase B (PI3K-AKT) network is a critical intracellular signaling pathway.
- It is activated by cytokines and growth factors, regulating vital cellular processes.
- Dysregulation of this network is linked to various diseases, including cancer and diabetes mellitus.
Purpose:
- To review the role of the PI3K-AKT network in cellular responses.
- To explore its involvement in pathological viral and bacterial infections.
- To discuss potential therapeutic strategies targeting this network.
Summary:
- The PI3K-AKT pathway controls cell proliferation, survival, metabolism, and more.
- Genomic alterations in this network contribute to cancer and other diseases.
- It also plays a role in viral infections, including Epstein-Barr, hepatitis C, hepatitis B, and HIV, influencing latent, chronic, and malignant stages.
- The network's involvement extends to tumorigenic viral infections, affecting malignant transformation.
Impact:
- Understanding the PI3K-AKT network's role in disease is crucial for developing new treatments.
- Targeting the PI3K-AKT pathway offers a potential strategy for antiviral therapies.
- Inhibiting PI3K-AKT activity may prevent malignant transformation associated with tumorigenic viral infections.
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