Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Delirium is associated with early postoperative cognitive dysfunction.

J L Rudolph1, E R Marcantonio, D J Culley

  • 1VA Boston Healthcare System, Geriatric Education and Clinical Center; Brigham and Women's Hospital, Division of Aging, Harvard Medical School, Boston, MA, USA. jrudolph@partners.org

Anaesthesia
|June 13, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multivariable model of postoperative delirium in cardiac surgery patients: proteomic and demographic contributions.

medRxiv : the preprint server for health sciences·2023
Same author

Exploring the limits of prolonged apnoea with high-flow nasal oxygen: an observational study.

Anaesthesia·2020
Same author

Red blood cell transfusion in surgery: an observational study of the trends in the USA from 2011 to 2016.

Anaesthesia·2019
Same author

Association of preoperative anaemia with postoperative morbidity and mortality: an observational cohort study in low-, middle-, and high-income countries.

British journal of anaesthesia·2018
Same author

Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery-20181.

Journal of Alzheimer's disease : JAD·2018
Same author

Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.

British journal of anaesthesia·2018
Same journal

Pulmonary artery catheters or central venous catheters for cardiac surgery: the PUMA Pilot randomised clinical trial.

Anaesthesia·2026
Same journal

Opioid-free vs. opioid-inclusive anaesthesia with or without regional anaesthesia for postoperative pain.

Anaesthesia·2026
Same journal

Optimal dose of intra-operative dexmedetomidine for postoperative delirium prevention: a reply.

Anaesthesia·2026
Same journal

Optimal dose of intra-operative dexmedetomidine for postoperative delirium prevention.

Anaesthesia·2026
Same journal

Pain control or brain protection with esketamine: a reply.

Anaesthesia·2026
Same journal

A step forward for patient-centred fasting guidelines: a reply.

Anaesthesia·2026
See all related articles

Postoperative delirium is linked to early cognitive problems after surgery. However, the study found no clear association between delirium and long-term cognitive dysfunction in older adults.

Area of Science:

  • Geriatric Medicine
  • Neuroscience
  • Anesthesiology

Background:

  • Postoperative cognitive dysfunction (POCD) is a significant concern in elderly patients undergoing surgery.
  • Delirium is a common complication following surgery, particularly in older individuals.
  • The relationship between postoperative delirium and subsequent cognitive deficits requires further elucidation.

Purpose of the Study:

  • To investigate the association between postoperative delirium and early (7-day) and long-term (3-month) postoperative cognitive dysfunction (POCD).
  • To analyze cognitive outcomes in elderly surgical patients who experienced delirium.

Main Methods:

  • Recruited 1218 subjects aged 60+ undergoing elective non-cardiac surgery.
  • Assessed patients for delirium postoperatively using DSM criteria.

Related Experiment Videos

  • Administered neuropsychological tests pre-operatively and at 7 days and 3 months postoperatively to assess POCD.

    • Main Results:

    • Delirium was associated with a higher incidence of early POCD (adjusted risk ratio 1.6).
    • No significant association was found between delirium and long-term POCD (adjusted risk ratio 1.3).
    • Subjects with delirium were less likely to complete postoperative testing.

    Conclusions:

    • Postoperative delirium is linked to early cognitive impairment following surgery.
    • The association between delirium and long-term cognitive dysfunction remains uncertain.
    • Further research is needed to clarify the long-term impact of delirium on cognitive function in surgical patients.