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SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients
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Published on: February 6, 2021

Delirium is associated with early postoperative cognitive dysfunction.

J L Rudolph1, E R Marcantonio, D J Culley

  • 1VA Boston Healthcare System, Geriatric Education and Clinical Center; Brigham and Women's Hospital, Division of Aging, Harvard Medical School, Boston, MA, USA. jrudolph@partners.org

Anaesthesia
|June 13, 2008
PubMed
Summary
This summary is machine-generated.

Postoperative delirium is linked to early cognitive problems after surgery. However, the study found no clear association between delirium and long-term cognitive dysfunction in older adults.

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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

Area of Science:

  • Geriatric Medicine
  • Neuroscience
  • Anesthesiology

Background:

  • Postoperative cognitive dysfunction (POCD) is a significant concern in elderly patients undergoing surgery.
  • Delirium is a common complication following surgery, particularly in older individuals.
  • The relationship between postoperative delirium and subsequent cognitive deficits requires further elucidation.

Purpose of the Study:

  • To investigate the association between postoperative delirium and early (7-day) and long-term (3-month) postoperative cognitive dysfunction (POCD).
  • To analyze cognitive outcomes in elderly surgical patients who experienced delirium.

Main Methods:

  • Recruited 1218 subjects aged 60+ undergoing elective non-cardiac surgery.
  • Assessed patients for delirium postoperatively using DSM criteria.
  • Administered neuropsychological tests pre-operatively and at 7 days and 3 months postoperatively to assess POCD.

Main Results:

  • Delirium was associated with a higher incidence of early POCD (adjusted risk ratio 1.6).
  • No significant association was found between delirium and long-term POCD (adjusted risk ratio 1.3).
  • Subjects with delirium were less likely to complete postoperative testing.

Conclusions:

  • Postoperative delirium is linked to early cognitive impairment following surgery.
  • The association between delirium and long-term cognitive dysfunction remains uncertain.
  • Further research is needed to clarify the long-term impact of delirium on cognitive function in surgical patients.