Related Experiment Video
Updated: Jan 1, 2026
09:45
Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
Published on: January 24, 2025
6.4K
Opisthotonus in neurosyphilis: a case report
Vijai V Chauhan1, Andrew T Pickens
1Division of Emergency Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
The Journal of Emergency Medicine
|June 13, 2008
Summary
Neurosyphilis, a late-stage syphilis infection, can cause severe neurological symptoms like decreased consciousness and cognitive decline. Prompt diagnosis and treatment are crucial for managing this serious condition.
Area of Science:
- Neurology
- Infectious Diseases
- Medical Diagnostics
Background:
- Neurosyphilis is a re-emerging infectious disease affecting the central nervous system.
- Late-stage syphilis can manifest with diverse and severe neurological complications.
Observation:
- A 40-year-old female presented with decreased consciousness and cognitive decline.
- Recurrent opisthotonus episodes and prior leg weakness were noted.
- Previous serological tests for syphilis were reactive.
Findings:
- Cerebrospinal fluid analysis revealed positive Venereal Disease Research Laboratory (VDRL) and fluorescent treponemal antibody absorption (FTA-ABS) tests.
- Brain magnetic resonance imaging (MRI) showed abnormalities.
- Diagnosis of neurosyphilis was confirmed.
Implications:
- Highlights the importance of considering neurosyphilis in patients with unexplained neurological deterioration.
- Emphasizes the utility of serological and cerebrospinal fluid testing in diagnosis.
- Underscores the need for timely intervention in neurosyphilis cases.
