Related Experiment Video
Updated: Jul 4, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
Immune regulation by histamine H4 receptors in skin
1Swiss Institute of Allergy and Asthma Research, Davos, Switzerland. akdisac@siaf.unizh.ch
Abstract:
The diverse effects of histamine on immune regulation appear to be due to differential expression and regulation of four types of histamine receptors and their distinct intracellular signals. The differences in cellular expression and affinities of these receptors for histamine determine the biological effects of histamine and the drugs that target histamine receptors. In this issue, Dijkstra et al., demonstrate the expression and some of the functions of histamine H(4) receptors on inflammatory dendritic cells in atopic dermatitis skin.
Related Concept Videos
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Allergic Reactions: Anaphylaxis
Allergic Drug Reactions
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
