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Related Experiment Video

Updated: Jul 4, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

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Multivessel variant angina after a radical nephrectomy operation.

Ertan Ural¹, Teoman Kilic, Göksel Kahraman

¹Department of Cardiology, Kocaeli University Medical Faculty, Kocaeli, Turkey.

The Canadian Journal of Cardiology

|June 13, 2008

Summary

Variant angina, a form of coronary artery vasospasm, can occur after radical nephrectomy (RNO). Beta-blockers may worsen this condition, necessitating a switch to calcium channel blockers for effective treatment.

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Area of Science:

Cardiology
Cardiovascular Surgery

Background:

Radical nephrectomy (RNO) is a surgical procedure for kidney removal.
Acute coronary syndromes (ACS) are common post-operative complications.

Observation:

A 52-year-old male presented with recurrent chest pain and ECG changes post-RNO.
Initial diagnosis was non-ST segment elevation ACS, but symptoms recurred despite beta-blocker therapy.

Findings:

Emergency angiography revealed multivessel coronary artery narrowing during chest pain, relieved by nitroglycerin.
Diagnosis of variant angina (coronary vasospasm) was confirmed.
Beta-blocker therapy was discontinued and replaced with calcium channel blockers, resolving symptoms.

Implications:

Coronary vasospasm should be considered in patients with recurrent angina post-RNO.
Beta-blockers can be detrimental in variant angina and should be used cautiously.
Prompt diagnosis and appropriate medical management are crucial for favorable outcomes.