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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

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Published on: December 28, 2017

[Echinocandins in invasive candidiasis].

Andreas Glöckner¹, Oliver A Cornely

¹Neurologisches Rehabilitationszentrum, Greifswald. a.gloeckner@nrz-greifswald.de

Medizinische Klinik (Munich, Germany : 1983)

|June 13, 2008

Summary

Echinocandins are a new antifungal drug class effective against invasive candidiasis, a common ICU infection. They offer improved safety and efficacy, becoming a preferred treatment for critically ill patients.

Area of Science:

Infectious Diseases
Pharmacology
Critical Care Medicine

Context:

Invasive fungal infections, primarily candidemia caused by Candida spp., pose a significant threat in intensive care units (ICUs).
Despite advances, invasive candidiasis mortality remains high (20-50%).
Echinocandins emerged in the 21st century as a novel antifungal class.

Purpose:

To evaluate the efficacy and safety of echinocandins (anidulafungin, caspofungin, micafungin) compared to standard treatments for invasive candidiasis.
To highlight the benefits of echinocandins in complex ICU patient populations.

Summary:

Echinocandins demonstrate noninferiority to standard antifungal therapies in phase III clinical trials.
Anidulafungin showed superiority against fluconazole in specific trials.

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Echinocandins were associated with fewer treatment-related adverse events, particularly when compared to amphotericin B.

Impact:

Echinocandins offer a favorable safety profile with low drug-drug interactions and minimal impact from liver dysfunction.
Their characteristics make them the preferred first-line treatment for invasive candidiasis in ICU patients with organ failure and polypharmacy.