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Effect of surface energy on powder compactibility.
Frauke Fichtner1, Denny Mahlin, Ken Welch
1Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Pharmaceutical Research
|June 13, 2008
Summary
Surface energy significantly impacts lactose powder compactibility. Decreased surface energy, influenced by surfactants like polysorbate 80, correlates with reduced tablet strength, highlighting the role of intermolecular forces in particle bonding.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Surface energy is a critical factor in powder behavior.
- Understanding its influence on compactibility is essential for tablet formulation.
Purpose of the Study:
- To investigate how surface energy affects lactose particle compactibility.
- To determine the role of surfactants in modifying surface energy and subsequent tablet properties.
Main Methods:
- Spray drying of lactose with and without polysorbate 80.
- Characterization of powder surface energy using Inverse Gas Chromatography.
- Analysis of tablet compressibility and compactibility through tensile strength measurements.
Main Results:
- All lactose powders were amorphous with similar particle size, shape, and surface area.
- Powder compressibility and tablet microstructure remained consistent across formulations.
- Powder compactibility and dispersive surface energy were dependent on powder composition, particularly surfactant presence.
Conclusions:
- Tablet strength decreases as powder surface energy decreases at constant porosity.
- Tablet strength is governed by intermolecular forces at particle contact points.
- Surface energy, and thus tablet strength, can be modulated by incorporating surfactants.
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