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[Fever, nosebleeding and myalgic abdominal pain]
1Klinik für Innere Medizin V-Nephrologie und Hypertensiologie, Klinikum Chemnitz gGmbH, Chemnitz. michael.leopold2@freenet.de
Praxis
|June 14, 2008
Summary
Hemorrhagic fever with renal syndrome (HFRS), a Hantavirus infection, presents with fever, abdominal pain, and acute kidney injury. The milder Nephropathia epidemica form, often caused by Puumala virus, typically requires minimal intervention.
Area of Science:
- Nephrology
- Infectious Diseases
- Virology
Background:
- Hemorrhagic Fever with Renal Syndrome (HFRS) is a zoonotic disease caused by Hantaviruses.
- Nephropathia epidemica (NE) is a milder form of HFRS, commonly associated with the Puumala virus.
- Differential diagnosis for acute renal failure with systemic symptoms is crucial.
Observation:
- A 38-year-old patient presented with a five-day history of fever, myalgic abdominal pain, epistaxis, and acute renal failure.
- Clinical presentation included thrombocytopenia, proteinuria, elevated C-reactive protein (CrP), and creatinine.
- These symptoms are characteristic of Hantavirus infection.
Findings:
- The patient's presentation aligns with Hemorrhagic Fever with Renal Syndrome (HFRS).
- The specific constellation of symptoms suggests a Hantavirus etiology, potentially the Puumala virus given the benign course implied by infrequent dialysis requirement.
- Laboratory findings of thrombocytopenia, proteinuria, elevated CrP, and creatinine support the diagnosis.
Implications:
- Early recognition of HFRS symptoms is vital for timely diagnosis and management.
- Distinguishing Hantavirus infections from other causes of acute kidney injury and fever is essential for appropriate patient care.
- Understanding the spectrum of Hantavirus disease, including Nephropathia epidemica, aids in predicting patient outcomes and treatment needs.
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