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Related Concept Videos

Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
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Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
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Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
Drug toxicity: Drug–Drug Interaction01:30

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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
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[Drug-induced toxic hepatitis].

O Kummer1, F Hammann, M Bodmer

  • 1Klinische Pharmakologie & Toxikologie, Universititsspital Basel. oliver.kummer@unibas.ch

Praxis
|June 14, 2008
PubMed
Summary
This summary is machine-generated.

A patient developed toxic hepatitis after consuming Traditional Chinese Medicine (TCM). Symptoms resolved after discontinuing the TCM preparation and other medications, suggesting a possible causal link.

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Area of Science:

  • Hepatology
  • Toxicology
  • Traditional Chinese Medicine (TCM)

Background:

  • A 55-year-old male presented with severe nausea, vomiting, and jaundice, indicating significant hepatocellular damage.
  • The patient was undergoing treatment for acute sensory and motor neuropathy with gabapentin, esomeprazole, and prednisone.

Observation:

  • A Traditional Chinese Medicine (TCM) preparation, Hong Hua 29, was initiated 12 days before symptom onset.
  • Symptoms of toxic hepatitis, including elevated transaminases, were observed following the ingestion of Hong Hua 29.

Findings:

  • Exhaustive testing excluded other causes, leading to a diagnosis of toxic hepatitis.
  • Discontinuation of Hong Hua 29, gabapentin, and esomeprazole resulted in normalization of transaminase levels within three months.

Implications:

  • A potential causal relationship exists between Hong Hua 29 consumption and the observed toxic hepatitis.
  • This case highlights the importance of considering TCMs in differential diagnoses of drug-induced liver injury (DILI).
  • Further investigation into the hepatotoxicity of Hong Hua 29 is warranted.