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Related Experiment Videos

Systemic therapy for psoriasis.

Melvin Lee1, Robert E Kalb

  • 1State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Department of Dermatology, Buffalo, NY, USA.

Dermatology Nursing
|June 14, 2008
PubMed
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Biologic therapy has revolutionized psoriasis treatment over the last decade. This review covers phototherapy, conventional systemic agents, and biologics for moderate to severe psoriasis.

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Psoriasis is a chronic inflammatory skin condition affecting millions worldwide.
  • Therapeutic options have evolved significantly, particularly with advancements in biologic agents.
  • Managing moderate to severe psoriasis requires a comprehensive understanding of available treatments.

Purpose of the Study:

  • To review current therapeutic strategies for moderate to severe psoriasis.
  • To discuss the administration and application of phototherapy, conventional systemic therapy, and biologic therapy.
  • To provide insights into overall treatment approaches and special considerations for individual therapies.

Main Methods:

  • Review of current literature on psoriasis treatment modalities.

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  • Discussion of phototherapy, conventional systemic agents (e.g., methotrexate, cyclosporine), and biologic therapies (e.g., TNF inhibitors, IL-17 inhibitors, IL-23 inhibitors).
  • Inclusion of practical administration tips and considerations for patient management.

    • Main Results:

    • Biologic therapies represent a major advancement in managing moderate to severe psoriasis.
    • Phototherapy and conventional systemic therapies remain valuable options, especially in specific clinical scenarios.
    • Tailoring treatment based on disease severity, patient factors, and individual therapy advantages is crucial.

    Conclusions:

    • The landscape of psoriasis treatment has been transformed by biologic therapies.
    • A multi-modal approach, integrating various treatment types, is often necessary for optimal patient outcomes.
    • Understanding the nuances of each therapeutic class allows for personalized and effective psoriasis management.