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Updated: Jul 4, 2026

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Published on: March 8, 2024
Neurectomy versus neurolysis for Morton's neuroma
Carlos Villas1, Borja Florez, Matias Alfonso
1Department of Orthopaedic Surgery and Traumatology, Clínica Universitaria de Navarra, Avda Pio XII 36, 31080 Pamplona Navarra Spain. cvillas@unav.es
Background:
We evaluated a series of patients who underwent neurectomy or neurolysis for the surgical treatment of Morton's neuroma.
Materials And Methods:
A group of 50 patients (69 feet) who underwent surgery for a symptomatic Morton's neuroma were retrospectively reviewed. Surgery was performed through a dorsal approach in all cases. When the nerve showed macroscopic thickening or the typical pseudoneuroma, it was resected; when the nerve had no macroscopic changes, the intermetatarsal ligament and any other potentially compressive structure were released. In 17 cases, adjacent claw toes were treated.
Results:
Nerve thickening (pseudoneuroma) were resected in 46 cases; in the other 23 cases, the nerve was preserved. Total relief from digital nerve related symptoms was obtained in all cases but one in each group. These patients were reoperated on 6 months later by performing a neurectomy in the case where the nerve had been preserved, and a more proximal resection in the case in which the nerve had been resected. Both patients finally achieved complete pain relief.
Conclusion:
When treating Morton's neuromas surgically, neurolysis can be a valid option when a pseudoneuroma has not developed.
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