Neurectomy versus neurolysis for Morton's neuroma
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Updated: Jul 4, 2026

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Published on: March 8, 2024
Carlos Villas1, Borja Florez, Matias Alfonso
1Department of Orthopaedic Surgery and Traumatology, Clínica Universitaria de Navarra, Avda Pio XII 36, 31080 Pamplona Navarra Spain. cvillas@unav.es
Background:
We evaluated a series of patients who underwent neurectomy or neurolysis for the surgical treatment of Morton's neuroma.
Materials And Methods:
A group of 50 patients (69 feet) who underwent surgery for a symptomatic Morton's neuroma were retrospectively reviewed. Surgery was performed through a dorsal approach in all cases. When the nerve showed macroscopic thickening or the typical pseudoneuroma, it was resected; when the nerve had no macroscopic changes, the intermetatarsal ligament and any other potentially compressive structure were released. In 17 cases, adjacent claw toes were treated.
Results:
Nerve thickening (pseudoneuroma) were resected in 46 cases; in the other 23 cases, the nerve was preserved. Total relief from digital nerve related symptoms was obtained in all cases but one in each group. These patients were reoperated on 6 months later by performing a neurectomy in the case where the nerve had been preserved, and a more proximal resection in the case in which the nerve had been resected. Both patients finally achieved complete pain relief.
Conclusion:
When treating Morton's neuromas surgically, neurolysis can be a valid option when a pseudoneuroma has not developed.
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