Related Experiment Video
Updated: Jul 4, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
Can following the caloric restriction recommendations from the Dietary Guidelines for Americans help individuals lose
Robert A Carels1, Kathleen M Young, Carissa Coit
1Department of Psychology, Bowling Green State University, Bowling Green, OH 43403, USA. rcarels@bgsu.edu
Background:
The Dietary Guidelines for Americans recommend creating an energy deficit of at least 500 kcal a day to facilitate weight loss. This investigation examined the relationship between creating a consistent, self-reported energy deficit of at least 500 kcal a day and weight loss. The relationship between self-monitoring adherence and daily energy intake and expenditure and weight loss was also examined.
Methods:
Fifty-four overweight or obese adults (BMI>or=27 kg/m(2)) participating in a 14-week weight loss program were given a 5% total body weight loss goal and instructed to create an energy deficit of at least 500 kcal a day to facilitate weight loss. Participants provided daily records of total energy intake and expenditure, physical activity, and weekly and overall weight loss during treatment.
Results:
Individuals who averaged an energy deficit in excess of 500 kcal per day lost nearly four times the weight as individuals whose average energy deficit was below 500 kcal per day (p<.01). Individuals who lost 5% of their body weight during the intervention self-monitored more than twice as many days than individuals who failed to lose 5% of their body weight (p<.01).
Conclusion:
Individuals interested in losing weight should continue to be advised to regularly self-monitor energy intake and expenditure as well as to create a consistent daily energy deficit (e.g., 500 kcal day).
Related Concept Videos
Regulation of Food Intake
Energy Balance
Atherosclerosis III: Management
Obesity
Coronary Artery Disease IV: Preventive Measures
Binge Eating Disorders

