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Published on: August 4, 2021
Platelet-derived microparticle levels in women with recurrent spontaneous abortion
Kürşat Kaptan1, Cengiz Beyan, Ahmet Ifran
1Department of Hematology, Gülhane Military Medical Academy, Ankara, Turkey. mkkaptan@hotmail.com
Objective:
To investigate the significance of platelet-derived microparticles (PMPs) in women with recurrent spontaneous abortion.
Methods:
We measured platelet P-selectin (CD62P) as a platelet activation marker and CD42b(+) microparticles as PMPs by flow cytometry in whole blood of 20 women with recurrent spontaneous abortion and 20 age-matched healthy controls with no previous history of spontaneous abortion.
Results:
PMP levels in women with recurrent spontaneous abortion were higher than in women in the control group (4.79+/-1.18% vs 3.06+/-0.92%; P<0.000). CD62P levels were not significantly higher in the study group compared with the control group (13.78+/-8.62% vs 10.78+/-7.35%; P>0.05).
Conclusion:
Our findings suggest that PMPs may have a role in the pathogenesis of recurrent spontaneous abortion.
