Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...

Parkinson Disease ll: Pathophysiology

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

Parkinson Disease l: Introduction

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Citizen seismology helps decipher the 2021 Haiti earthquake.

Science (New York, N.Y.)·2022

Same author

Cognitive and behavioural post-traumatic impairments: what is the specificity of a brain injury ? A study within the ESPARR cohort.

Annals of physical and rehabilitation medicine·2014

Same author

Prognostic factors of long-term outcome in cases of severe traumatic brain injury.

Annals of physical and rehabilitation medicine·2014

Same author

Does the rectus femoris nerve block improve knee recurvatum in adult stroke patients? A kinematic and electromyographic study.

Gait & posture·2013

Same author

Clinical signs and radiographic evidence of esophageal perforation after tetraplegia.

Annals of physical and rehabilitation medicine·2013

Same author

Oral anticoagulant treatment - evaluating the knowledge of patients admitted in physical medicine and rehabilitation units.

Annals of physical and rehabilitation medicine·2011

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

[Deep brain stimulation and Parkinson's disease].

¹Service de rééducation neurologique, hôpital Henry-Gabrielle, hospices civils de Lyon, 20, route de Vourles, 69230 Saint-Genis-Laval, France. dominique.boisson@chu-lyon.fr

Annales De Readaptation Et De Medecine Physique : Revue Scientifique De La Societe Francaise De Reeducation Fonctionnelle De Readaptation Et De Medecine Physique

|June 14, 2008

Summary

Deep brain stimulation (DBS) offers a reversible treatment option for advanced Parkinson's disease (PD). This neurosurgical approach, targeting specific brain areas, has evolved to consider quality of life and social adaptation for patients.

More Related Videos

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Related Experiment Videos

Last Updated: Jul 4, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Area of Science:

Neurology and Neurosurgery
Neuroscience
Medical Technology

Context:

Emergence of high-frequency stimulation as a non-ablative stereotactic surgical treatment for Parkinson's disease (PD).
Evolution from treating advanced PD to earlier indications based on refined selection criteria and patient collaboration.
Development of medicosurgical collaborations within specialized centers for PD management.

Purpose:

To review the evolution and current practices of deep brain stimulation (DBS) for Parkinson's disease.
To discuss the main targets (Vim, GPI, STN) and the adjustable, reversible nature of DBS.
To highlight the shift towards considering patient quality of life and social adaptation in treatment decisions.

Summary:

Deep brain stimulation (DBS) utilizes high-frequency stimulation targeting specific brain regions (Vim, GPI, STN) for reversible functional inhibition in PD.
Indications have broadened from advanced, medically refractory PD to earlier stages, with careful patient selection and perioperative control.
Multicenter studies and follow-up data have validated practices, with a growing prevalence of subthalamic nucleus targeting in Europe.

Impact:

DBS has improved the understanding of Parkinson's disease pathophysiology and treatment.
While not altering the long-term prognosis, DBS enhances motor control and patient quality of life.
Ongoing technological advancements offer continued hope for managing PD and related neurodegenerative conditions.