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An open-access, very-low-field MRI system for posture-dependent 3He human lung imaging.

L L Tsai1, R W Mair, M S Rosen

  • 1Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, MS 59, Cambridge, MA 02138, USA.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|June 14, 2008
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We developed an open-access, low-field magnetic resonance imaging (MRI) system for hyperpolarized helium-3 (3He) lung imaging. This system enables upright and supine imaging, crucial for studying lung function in conditions like asthma and obesity.

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Area of Science:

  • Medical Imaging
  • Pulmonary Physiology
  • Biophysics

Background:

  • Hyperpolarized 3He MRI offers unique insights into lung function.
  • Previous systems were limited in posture flexibility.
  • Assessing lung function in various postures is vital for understanding diseases like asthma and obesity.

Purpose of the Study:

  • To design and operate an open-access, very-low-field MRI system for in vivo hyperpolarized 3He lung imaging.
  • To enable imaging in both horizontal and upright postures.
  • To facilitate research in pulmonary physiology and clinical medicine.

Main Methods:

  • Utilized a bi-planar B(0) coil design for a 6.5 mT magnetic field.
  • Employed bi-planar coils for gradient generation with a 79-cm inter-coil gap.
  • Used solenoidal Q-spoiled RF coils for low-frequency operation and pre-calibration.

Main Results:

  • Achieved sufficient signal-to-noise ratio (SNR) for 2D 3He images with 2.8mm resolution.
  • Acquired initial 2D and 3D 3He images of human lungs in supine and upright orientations.
  • Demonstrated the capability for concurrent 1H MRI for diagnostic and calibration purposes.

Conclusions:

  • The developed system provides a novel platform for upright and supine hyperpolarized 3He lung MRI.
  • This technology has significant potential for advancing the study of lung diseases and physiology.
  • The open-access nature promotes broader research and clinical applications.