Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Working Memory01:24

Working Memory

Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this information.
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the cerebellum's...
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Ā Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is critical for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterisation of Posterior Predominant Amyloid PET Binding Across Multiple Cohorts.

bioRxiv : the preprint server for biologyĀ·2026
Same author

Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers.

JAMA neurologyĀ·2026
Same author

Features predicting data exclusion in imaging studies of Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)Ā·2026
Same author

Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications.

Alzheimer's & dementia : the journal of the Alzheimer's AssociationĀ·2026
Same author

Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in Alzheimer's disease (HEAD): a multicentre, prospective, cross-sectional, within-participant study.

Lancet (London, England)Ā·2026
Same author

Association of neighborhood deprivation with Alzheimer's Disease pathology, brain structure, and cognition by race and ethnicity, sex, and APOE Īµ4 status.

medRxiv : the preprint server for health sciencesĀ·2026

Related Experiment Video

Updated: Jul 4, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Striatal dopamine and working memory.

Susan M Landau1, Rayhan Lal, James P O'Neil

  • 1Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720-3190, USA. slandau@berkeley.edu

Cerebral Cortex (New York, N.Y. : 1991)
|June 14, 2008
PubMed
Summary
This summary is machine-generated.

Dopamine in the brain

More Related Videos

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice
17:45

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Published on: February 26, 2012

Related Experiment Videos

Last Updated: Jul 4, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice
17:45

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Published on: February 26, 2012

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Dopamine pathways to the prefrontal cortex (PFC) are crucial for working memory (WM).
  • In vivo human studies on this dopamine-PFC system are limited.
  • Positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) enable direct measurement of dopamine and PFC activity.

Purpose of the Study:

  • To investigate the relationship between working memory capacity, dopamine levels, and prefrontal cortex function in healthy older adults.
  • To test the hypothesis linking these three factors.

Main Methods:

  • Utilized 6-[18F]fluoro-L-m-tyrosine PET to measure striatal dopamine synthesis capacity (caudate and putamen).
  • Employed event-related fMRI to assess brain activation during different working memory task phases (cue, delay, probe).

Main Results:

  • Caudate dopamine synthesis capacity positively correlated with working memory capacity.
  • Putamen dopamine synthesis capacity positively correlated with motor speed.
  • Delay-phase fMRI activation in the left inferior prefrontal cortex was associated with both caudate dopamine and task accuracy.

Conclusions:

  • Striatal dopaminergic function is linked to prefrontal cortex-dependent cognitive functions.
  • This study provides novel evidence for the role of dopamine in supporting working memory and prefrontal cortex activation in humans.
  • The left inferior prefrontal cortex may be a key region for integrating working memory maintenance processes.