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Published on: September 18, 2016
Colony-stimulating factors in inflammation and autoimmunity
1Arthritis and Inflammation Research Centre and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia. jahami@unimelb.edu.au
Nature Reviews. Immunology
|June 14, 2008
Summary
Colony-stimulating factors (CSFs), initially growth factors, now show therapeutic potential in autoimmune diseases by acting on myeloid cells. Clinical trials targeting specific CSFs are underway, exploring their benefits and risks.
Area of Science:
- Immunology
- Cell Biology
- Pharmacology
Background:
- Colony-stimulating factors (CSFs) were initially identified as hematopoietic-cell growth factors.
- Emerging evidence reveals CSFs possess additional functions, directly influencing mature myeloid cells.
- Recent animal studies suggest CSF depletion offers therapeutic advantages for inflammatory and autoimmune conditions.
Purpose of the Study:
- To describe the distinct biological features of CSFs.
- To discuss the probable in vivo outcomes of targeting CSFs.
- To highlight key questions for future research in CSF-targeted therapies.
Main Methods:
- Literature review of CSF biological functions.
- Analysis of preclinical animal model data.
- Discussion of clinical trial rationales and potential risks.
Main Results:
- CSFs exhibit multifaceted roles beyond hematopoiesis, impacting myeloid cell function.
- Targeting CSFs, such as granulocyte/macrophage colony-stimulating factor and macrophage colony-stimulating factor, shows promise in preclinical models of inflammatory and autoimmune diseases.
- Early-phase clinical trials have been initiated to evaluate CSF-targeted therapies.
Conclusions:
- The unique biological properties of CSFs present opportunities for targeted therapeutic strategies.
- Targeting CSFs may offer benefits in treating inflammatory and autoimmune disorders, but associated risks require careful consideration.
- Further research is needed to address outstanding questions regarding the specific outcomes and safety of CSF-targeted interventions.
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